• Key Enabling Technologies (KETs) – a group of six technologies: micro and nanoelectronics, nanotechnology, industrial biotechnology, advanced materials, photonics, and advanced manufacturing technologies – increase industrial innovation to address societal challenges and creating advanced and sustainable economies.
• Key Enabling Technologies (KETs) Observatory

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• Increasing synergies among synthetic biology, nanotechnology, 3D&4D printing, robotics, and the advent of AI, quantum computing, collective intelligence and yet to emerge technologies will make the past 25 years seem slow compared to the next 25 years.
• Most of the grand challenges we'll face by 2050 are technology-related, including: genetic modification of humans, safe car travel (self-driving or not), settling other worlds (space travel), boosted brainpower, and AI’s dominance in our lives. 
• Convergence of knowledge and technology for the benefit of society (CKTS) is the next stage.
• Per capita energy demand could peak before 2030, due to increased efficiency enabled by new technologies and stricter energy policies. | Related Megatrends: Natural resources; Consumerism
• Technological breakthroughs are needed for achieving carbon neutrality by 2050. Some technological solutions and initiatives are already either under development or even ready for the market --  raging from bio-enhancing materials that can merge with the
  natural environment, to energy distribution and transmission technologies and virtual power-plants.
• Frontiers of sciences are expanding – understanding of time, multidimensions, multiverse, teleportation, and of life itself. (e.g. the reversal of "arrow of time", multiverse, wearable technology, teleportation, and the list is expanding by the day).
• Teleportation, future-times camera and backwards time telegraph, which could be available in about 10 years, will transform our perception of time and space.

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• Synergies among engineering, physical sciences, computation, and life sciences are revolutionising medicine and health – advancing techniques to regenerate lost limbs and replace malfunctioning organs, tailored treatments for patients’ needs (using genomics and big data), while therapies to correct disease-causing genetic defects are already in clinical trials.
  | Related Megatrends: Health; Inequalities; Security
• Some of the new technology trends impacting the future of medicine include: individual approach to human neurophysiology; RNA aptamers, microchips under the skin and pocket biosensors; assistive medical technologies; genetic engineering technologies for creating highly specific drugs and molecular diagnostics tools; new diagnostics and therapy tols for individual approach at the cellular level;
• Using CRISPR -- genetic manipulation -- could help correct genetic helath issues before birth. 
  | Related Megatrends:  Health; Inequalities; Education; Security
• ​The pharmaceutical industry is increasingly driven by the need to move from treatment to prevention, diagnostics and cure, therefore speeding up innovation and implementation of new technological developments;
• By 2030, the pharmaceutical industry is expected to be radically different, with a shift in focus towards pharmatech, genetics and immunotherapy;
• Personalised medicine is increasingly adopted over the generic 'one size fits all' to better manage patients' health and targeted therapies to achieve the best outcomes depending on the patient's specifics. 
  | Related Megatrends:  Health; Inequalities; Security
• Artificial intelligence (AI) could offer the possibility to timely identify people prone to produce harm (to themselves or others), creating opportunities to intervene long before thoughts turn to action. 
  | Related Megatrends: Health; Inequalities; Security

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• Across OECD countries, R&D intensity (R&D spending as a percentage of GDP ) was 2.37% in 2017, a slight increase compared to 2.34% in 2016, but about stable for the past five years. Korea and Israel rank the highest (4.55% and 4.54% respectively), in USA was 2.78, while China continued its steady increase – reaching 2.13% and set to be on par with the OECD by 2020.
• China aims to become the world leader in science and innovation by 2050. Its rate of R&D investment growth significantly exceeds that of the USA and the EU. In 2017, R&D spending (PPP$) of China – $496 billion —was second to the USA's $543 billion and 15% over the EU28's $427.6 billion.
• China plans to be world leader in AI by 2030.
  ​​| Related Megatrends: Geopower; Security; Governance
• In the EU, R&D intensity increased to 2.07% in 2017 compared to 2.04% in 2016 and a considerable increase compared to 1.77% in 2007.
• The EU share of world R&D is 26%. 
  | Related Megatrends: Geopower; Security; Inequalities
• EU countries spend around 2% of their GDP on R&I – ranging from barely 0.2% in Romania to more than 3% in Finland – with the private rather than public sector having the biggest budgets — skewed towards close-to-market product development rather than frontier research.
  ​| Related Megatrends: Inequalities; Geopower
• For the EU area, the return on public investment in R&I is of the order of 20-50%, considerably higher than long-term Euro area government bonds at 3.1%, or the past 10 years of the USA stock market 6.8% annual return.
• Of the 10 most powerful supercomputers, the top two are in the USA, followed by two in China; one in Switzerland ranks 6th, one in Japan 8th, one in Germany ranks 9th and the other three are in the USA. The USA Department of Energy and Intel joined the race for building the world’s first exascale supercomputer.
• EU is developing 8 supercomputers to be operational at mid-2020. They will be hosted at eight centres across the EU. Three of them, precursor to exascale machines (capable of executing more than 150 million billion calculations per second) will be in the top 5 supercomputers of the world. The other 5 will be petascale machines (capable of executing at least 4 Petaflops, or 4 million billion operations per second). They will support Europe's researchers, industry and businesses in a wide range of areas, from fighting climate change to designing medicines and new materials.
• USA invests $249 million in quantum information science, to "ensure sustained American leadership in a field likely to shape the long-term future of information processing”.
• India's digital sector to be a $1 trillion economy by 2023.​​
• S&T opens opportunity for job creation; in India—that has 600 million people under the age of 25, hence, needs many jobs over the next years—it is estimated that a new technology creates 100 new jobs for each 10 potentially displaced. 
  ​| Related Megatrends: Work; Inequalities; Geopower; Security
• 90% of inventions in environment-related technologies originate in OECD countries, especially Japan, the United States, Germany, Korea and France. 
  ​​| Related Megatrends: Natural resources; Climate and environment

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For technology to benefit the many, social and economic gaps have to be addressed, knowledge shared, technology literacy and skills increased, and education system updated.

Democratization of science

• There is a democratization of science, with citizen science projects like Galaxy Zoo and Higgs Hunters, blurring the lines between public engagement, education and professional science research.
  | Related Megatrends: Work; Inequalities; Governance; 
  Security; Education
• Methods of engineering microorganisms' DNA are readily available and getting more powerful. A “do it yourself” movement is starting to shift genetic engineering out of large institutions and into DIY labs or people’s homes. Home kits to modify the genes of bacteria using CRISPR are on sale online for $140.
• Increasingly open science, sharing of research results, free circulation of knowledge and transparency in methodology, digitalization and growing capacity of data analysis increase collaborative cross-disciplinary research, pooling together resources, brainpower and complementary expertise, thus accelerating innovation. | Related Megatrends: Work; Inequalities; Security; Education

Economic concentration

• There is a concentration of R&D activity, with a small number of firms being responsible for a large proportion of total business R&D: the headquarters of the top 2,000 R&D corporations worldwide are concentrated in just a few economies (mainly USA, Japan and China), own about 75% of global ICT-related patents, 55% of ICT-related designs and 75% of the IP5 patent families related to AI, and about 70% of their total R&D spending is concentrated in the top 200 firms.
  | Related Megatrends: Inequalities; Geopower; Security
• The number of influential technology companies is expected to shrink from 70 in 2017 to 30 by 2030 and possibly 10 by 2050, increasing the digital oligarchy. 

Increasing power of China

• China has the top 3rd and 4th most powerful supercomputers, (were top two until overtaken by IBM Power Systems in the USA).
• China accounts for 44% of worldwide M2M (machine-to-machine) sim card subscriptions – three times the share of the USA.
  ​| Related Megatrends: Inequalities; Geopower; Security
• Chinese aims to become world leader in science and innovation by 2050. In 2017, China's R&D spneding of about $378.6 billion (PPP) accounted for 21% of total world R&D expenditure, with the rate of R&D investment growth significantly exceeding that of the U.S. and the EU.
• China plans to be world leader in AI by 2030. Its R&D intensity might match that of OECD by 2020.
  | Related Megatrends: Geopower; Security; Inequalities;
  Governance 

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• As algorithms play an increasingly important role in governing our life, the codes of ethics that rule algorithms-writing, access and use of data and the way we address AI will have a determining impact on our future.  'AI for society' implies AI systems 'secure and ethical by design'.
• AI and IoT bringing many benefits to our society, including greater inclusion and access to information, goods and services, and improve military systems. Nevertheless, they also carry significant risks, such as erosion of individual privacy, misinformation, misuse of data, increasing cybersecurity threats, and boost weapons capabilities in the hands of state as well as non-state actors.
• Fintech increases efficiency of operations in the financial sector and promotes innovation and job creation, but also raises concerns such as data and consumer protection, exacerbating risk of financial volatility or cybercrime. 
• Digitalizing the energy  and other infrastructure systems increase efficiency, reduce CO2 emissions and costs, but increase the risks of cyber-attacks and other security issues.
• Emerging technologies, bio, nano, chemo, exponentially increase the threats of (t)error incident(s). Warfare will increasingly include cyber-weapons, unmanned remote-controlled warfare, chemical and bio-weapons, militarisation of space, precision strike capability. 
• While CRISPR -- genetic manipulation -- could help address health issues, collection (and concentration) of biometric data would make possible hacking humans and other living organism and is increasing the risks of biological inequality and biological warfare, as well as re-engineering nature. 
  | Related Megatrends: Health; Inequalities; Security
• Social media and smartphones are increasingly seen as weapons of mass manipulation. In 2017, three billion people logged on to social media networks like Facebook, WhatsApp and China’s Sina Weibo, making it one of the most powerful tools for shaping peoples' thinking. Being an "influencer" is at the reach of anyone, 
  | Related Megatrends: Geopower; Inequalities; Security
• While lethal autonomous weapons systems (LAWS) are introducing the third revolution in warfare, increasing precision target and save lives, they could also be misused and are highly dependent of the codes of ethics and algorithms that govern them.
• Quantum cryptography is increasing communication security but also adds new challenges to intelligence gathering. | Related Megatrends: Security