The analysis of household resilience to food insecurity has become a key technical and evidence-based policy instrument for better tailoring development and humanitarian intervention designs. International development agencies must strengthen the capacity of vulnerable households to anticipate, cope with and adapt to shocks and stressors. Despite the humanitarian and development scope of household resilience strengthening, most resilience academic research and policies focused on protracted crises countries. Moreover, too little attention has been paid to in-depth gender inequality analysis in household resilience to food insecurity, and household food security. This paper aims to (i) analyse the key drivers of household resilience to food insecurity and (ii) assess differences in resilience capacity and food security indexes across male and female-headed households, and identify key drivers of these differentials in national, urban, and rural areas in the Gambia, by using Gambian Integrated Household Surveys on consumption expenditure and poverty-level assessment 2015–2016.