This Pathway seeks to provide a way forward for future R&I policy in Europe and beyond. It is 1 out of 10 FOOD 2030 Pathways for Action, which target key R&I leverage points for transitioning towards sustainable, resilient, healthy and inclusive food systems that leave no one behind. The FOOD Pathways for Action will help to underpin Horizon Europe, support evidence-based policymaking and implementation, foster education, skills and capacities, boost innovation and investment, encourage synergies and policy alignment. The achievement of these objectives will be assisted by a dedicated Horizon Europe Food Systems Partnership expected to be launched in 2023 that will provide a multi-actor R&I governance platform and process to deliver co-benefits in line with the European Green Deal. This pathway, The Microbiome World, is among others relevant to: health, food and nutrition security, addressing policy objectives of Green Deal and Farm to Fork strategy; energy security and climate change; delivering on climate ambition and targeted impact on climate neutrality and adaptation to climate change — addressing the new bioeconomy strategy for a sustainable Europe; soil Health and Food mission and others missions; Sustainable Development Goals (SDGs), namely 2, 3, 12, 13, 14 and 15.