Fragility has become a prevailing reality in an increasing number of countries in various areas, including Central and West Asia and North Africa (CWANA). The concept of fragility encompasses a range of dimensions, including armed conflict, migration, economic and political instability, erosion of the social fabric, and scarcity, depletion, and contamination of natural resources. The World Economic Forum’s recent survey data highlights the significant risks the region is least prepared to face, with water crises ranking among the top risks, followed by profound social instability, state collapse, and interstate conflict. These risks are all interconnected with situations of fragility posing existential threats to the prosperity and well-being of millions of people living in the region.