In an era of growing environmental, socioeconomic, and market uncertainties, understanding the adaptive strategies of smallholder farmers is paramount for sustainable agricultural productivity and environmental management efforts. We adopted a mixed-methods approach to investigate the adaptive strategies of smallholders in Northwest Cambodia. Our methodology included downscaled climate projections to project future climate conditions and scenarios, household surveys to collect detailed demographic and socioeconomic data, crop monitoring and record-keeping to gather data on productivity and profitability, and semi-structured interviews to obtain qualitative insights on constraints and adaptation. Our analyses revealed that all smallholders are increasingly vulnerable to climate change which projections reveal will result in more intense and extreme weather events. Specifically, 92% of respondents reported reductions in household income, and 63% indicated the necessity to cut household expenses, which negatively affect agricultural productivity, as evidenced by 33% of respondents reporting declining crop yields and 10% experiencing food shortages. We also uncovered significant differences in farming strategies to mitigate vulnerability among distinct household clusters. Some households prioritise maximising yields through high-expense production strategies, while others focus on optimising inputs to enhance profit-margins, indirectly minimising their environmental impact. These varying strategies have different implications for poverty, food security, and the environment, but were doing very little to mitigate overall vulnerability. To enhance the adaptive capacity of smallholders, policies should target interventions that balance economic growth with environmental sustainability, tailored to the specific needs of different farmer and household types. Promoting the adoption of climate-resilient agricultural practices, investing in water management infrastructure, enhancing access to timely and accurate climate information, and implementing social protection measures are strongly recommended.