Individual skills and talents, more than capital, are the driving forces that guide human beings towards the future. From 2013 through 2020, the business school INSEAD advanced the Global Talent Competitiveness Index (GTCI); since 2021, it has been released by Portulans Institute. The index aims to summarise complex and versatile concepts related to human capital and talent competitiveness at the national scale worldwide. In so doing, it raises conceptual and practical challenges that are discussed in the GTCI 2022 report. This chapter focuses on the practical challenges related to the data quality and the methodological choices made in the grouping of 69 variables into 14 sub-pillars, six pillars, two sub-indices, and an overall index for 133 countries.Individual skills and talents, more than capital, are the driving forces that guide human beings towards the future. From 2013 through 2020, the business school INSEAD advanced the Global Talent Competitiveness Index (GTCI); since 2021, it has been released by Portulans Institute. The index aims to summarise complex and versatile concepts related to human capital and talent competitiveness at the national scale worldwide. In so doing, it raises conceptual and practical challenges that are discussed in the GTCI 2022 report. This chapter focuses on the practical challenges related to the data quality and the methodological choices made in the grouping of 69 variables into 14 sub-pillars, six pillars, two sub-indices, and an overall index for 133 countries.