In sub-Saharan Africa, sustainable intensification of fruit production is affected by pests that strongly impact food and nutrition security. The invasive fruit fly, Bactrocera dorsalis, is a permanent threat to fruit crops, particularly mango. Direct loss is caused by larval feeding in the fruit, but significant indirect loss results when market opportunities are inaccessible due to quarantine restrictions. Another key pest is anthracnose, the most serious disease of mango worldwide. The combined effect of these pests threatens the sustainability of mango production systems, as current pest control methods are insufficient to minimize crop losses. Main objectives of the present project include (i) developing transformative pest control based on the use of insects as smart and reliable conveyors of biopesticides (entomovectoring), and (ii) co-designing with stakeholders biocontrol strategies as part of an integrated pest management framework. High-quality basic and applied research including lab and semi-field tests and small-scale field trials will be performed in Senegal and Kenya to optimize the interactions between insect conveyors (particularly sterile male fruit flies), entomopathogens, and target pests, assess environmental risk, and co-design pilot implementation with stakeholders. Expected results include the design of a two-in-one technology to control mango fruit flies and anthracnose. A key innovation of the project is the coordinated, preventive and area-wide approach, which ensures that all habitats of the target pest are treated, thus limiting re-invasion, as opposed to conventional strategies that focus on independent and often reactive grower interventions at the orchard scale.