Africa and the EU enjoy a long-standing partnership touching upon key fields such as peace and security, human rights, trade and socio-economic development. Science, technology and innovation (STI) play a fundamental role in our relations and are cross-cutting topics in the Joint Africa-EU Strategy. STI investments contribute directly to the attainment  of  all  socio-economic  development  objectives – including the United Nations Sustainable Development Goal targets – and are vital for promoting growth and employment, improving competitiveness, and identifying and addressing pressing global societal challenges. All  projects presented  in  this  publication  have been funded since 2010 through the EU  Framework  Programmes  for  Research  and Innovation. They showcase how our joint scientific efforts can produce ground-breaking results with a positive impact on local development and economic growth. All these projects cover important research areas such as water, food security, sustainable energy, climate change and health. In addition, they showcase  how  science  can  support  policy-making since it gives rise to the first concerted EU-Africa effort, deepening research cooperation in thematic priority areas and leading to the conception of the EU-Africa Research and Innovation Partnership on Food and Nutrition Security and Sustainable Agriculture. Today, just one year after the adoption of this initiative, Africa and Europe are working towards a second partnership which will have a special focus on climate change and sustainable energy. Research  and  innovation  will  continue  to  play a catalytic role in our overall relations with Africa.  Against  this  background,  the  EU remains firmly committed to fostering exchanges and good practices among African and European researchers and innovators with a view to building knowledge-based societies and economies across both continents.