This is the newsletter of the Regional Centre of Excellence against Hunger and Malnutrition. CERFAM’s Bulletin is a quarterly publication intended to inform you of the progress of food and nutrition security in West and Central Africa in particular and in Africa in general. The sixth issue of the CERFAM’s bulletin highlights: (i) the call of the UN Secretary-General Antonio Guterres for robust collective actions as part of the Food Systems Summit expected to take place in in September, 2021; (ii) the transformation of the food systems, fully aligned with the African Union's priorities, particularly Agenda 2063, to address food insecurity and malnutrition in Africa, (iii) a reminder from H.E. Josefa Sacko, Commissioner for Agriculture, Rural Development, Blue Economy and Sustainable Environment, African Union Commission (AUC) on the major challenges facing African countries, as well as the opportunities for "transformation" on the continent, (iv) an Open Letter to African Governments, written by Agnes Kalibata, Special Envoy for the 2021 Food Systems Summit, acknowledging that the success of the "People's Summit" including the transformation of the African continent rests on the involvement of everyone.